HDL Large measures the count of large, mature HDL particles, the most functional subfraction for reverse cholesterol transport.
Large HDL particles are the most efficient at reverse cholesterol transport. Higher counts correlate with cardiovascular protection; however, the HDL subfraction literature is less mature than LDL subfractions, so interpretation is supportive rather than decisive.
Optimal HDL Large (ION): 7000-15000 nmol/L.
Typically re-tested every 12 weeks.