HOMA2-%S estimates whole-body insulin sensitivity as a percentage, with 100% representing a reference healthy adult. It's the reciprocal of insulin resistance, computed from fasting glucose and fasting insulin via the HOMA2 computer model.
HOMA2-%S is the clearest way to frame insulin sensitivity for most people: higher is better, 100% is average, and values of 150%+ reflect athletic-level metabolic health. It's more intuitive than HOMA-IR for users who think in terms of "how well does my body handle carbs." Low HOMA2-%S with elevated HOMA2-%B is the classic early insulin-resistance signature, with beta cells still compensating but sensitivity declining.
Optimal HOMA2-%S: 85-200 %.
Typically re-tested every 10 weeks.