A compounded estriol and estradiol cream, with or without progesterone
From $180/mo with a 6-month plan A licensed provider reviews your intake and decides whether it's appropriate for you. Your provider picks your starting dose and adjusts it as you go.
Made by a licensed compounding pharmacy. Compounded medications are not FDA-approved.
100% online visit
Licensed providers in all 50 states
Ships in plain packaging
Message your care team anytime
How getting bi-est cream works
Tell us about your health. A short online intake: your history, medications and goals.
A licensed provider reviews it. They decide whether it's right for you and set your dose.
Treatment ships to you. In plain packaging. Track it, and message your care team, from Care.
What it is
Bi-est combines two estrogens, estriol and estradiol, in a cream applied to the skin. Some formulas add progesterone.
How it works in the body
Absorbed through the skin to replace falling estrogen during perimenopause and menopause.
What to expect
Weeks 2–6: Vasomotor symptoms like hot flashes often ease first.
May be a good fit if
You prefer a cream to a pill or patch
Menopause symptoms affecting daily life
Probably not for you if
History of breast or uterine cancer
History of blood clots or stroke
Doses your provider can prescribe
C-Biest (Estriol/Estradiol 50:50)
C-Biest (Estriol/Estradiol 50:50)/Progesterone
Common side effects
Breast tenderness
Spotting
Skin irritation where applied
Safety
A licensed provider reviews your intake and decides whether it's appropriate for you.
Made by a licensed compounding pharmacy. Compounded medications are not FDA-approved.
This isn't a full list. Your provider reviews your history and medications before prescribing.