The albumin to globulin ratio compares the two main types of proteins in blood plasma. Albumin is produced by the liver and serves many transport and oncotic functions; globulins include antibodies and other immune proteins. The ratio captures the balance between these two groups.
A low A:G ratio can indicate either reduced albumin (liver dysfunction, chronic illness, malnutrition) or elevated globulins (chronic infection, inflammation, some cancers). An elevated ratio is less common but can suggest immunodeficiency. The ratio is a useful screening tool that flags the need for more specific testing when abnormal, though it rarely drives diagnosis on its own.
Optimal Albumin:Globulin Ratio: 1.5-2 ratio.
Typically re-tested every 12 weeks.
Calculators that use Albumin:Globulin Ratio: